Sex pheromones and plasmid transfer in Enterococcus faecalis

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Sex pheromones and plasmid transfer in Enterococcus faecalis.

Plasmid-free Enterococcus faecalis excrete peptides (sex pheromones) which specifically induce a mating response in strains harboring certain conjugative plasmids. The response is characterized by the synthesis of a "fuzzy" surface material, visible by electron microscopy, which is believed to facilitate the aggregation of donors and recipients. Transconjugants which receive a specific plasmid ...

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Plasmid transfer in Streptococcus faecalis: production of multiple sex pheromones by recipients.

In a previous report (1978, Proc. Nat. Acad. Sci. USA 75, 3479-3483), we showed that recipient strains of Streptococcusfaecalis excrete a heat-stable substance (sex pheromone) which induces donor cells carrying certain conjugative plasmids to become adherent, generating the cell-to-cell contact necessary for plasmid transfer. Since donors themselves could be induced to aggregate or “clump” by r...

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Cell-cell communication mediated by peptide pheromones (cCF10 [CF]) is essential for high-frequency plasmid transfer in vitro in Enterococcus faecalis To examine the role of pheromone signaling in vivo, we established either a CF-producing (CF+) recipient or a recipient producing a biologically inactive variant of CF (CF- recipient) in a germfree mouse model 3 days before donor inoculation and ...

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Sex-Pheromone System and Plasmid Transfer in Enterococcus feacalis

Pheromone-inducible plasmid transfer is an important mechanism for dissemination of antibiotic resistance and virulence factors in these organisms. Plasmid-free strains of Enterococcus faecalis secrete at least half a dozen peptide sex pheromone-probably many more-that induce a mating response by potential donor strains carrying members of specific families of conjugative plasmids. The response...

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Sex pheromones and plasmid transfer in Streptococcus faecalis: a pheromone, cAM373, which is also excreted by Staphylococcus aureus.

Within a highly evolved mult icel lular organi sm, communicat ion between dis tally located ce l l s occurs by means o f a variety o f different chemica l s ignals . These hormonal substances play important roles in deve lopment , maintenance, and fertility and are a lso involved in coordinating immune and neurological responses to external st imuli . Chemical communicat ion can also occur betw...

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ژورنال

عنوان ژورنال: Plasmid

سال: 1989

ISSN: 0147-619X

DOI: 10.1016/0147-619x(89)90041-3